Analysis of the algorithm: From rankings to backup genes.

Ranking section

For each of the affected genes present in the list, a ranking with the score and percentile of every possible gene was obtained. Once this was done, the position for every known backup gene was obtained and the statistical descriptor of all the values calculated.

Table 1. Backup position values for every kernel and net before integration.

Net Kernel Elements Min Max Average Standard_Deviation
biological_process ct 51 0.0 0.921 0.056 0.159
biological_process el 51 0.0 0.906 0.074 0.198
biological_process ka 51 0.001 1.0 0.341 0.466
biological_process rf 51 0.0 0.917 0.056 0.16
cellular_component ct 3 0.001 0.294 0.165 0.122
cellular_component el 3 0.001 1.0 0.667 0.471
cellular_component ka 3 0.001 1.0 0.667 0.471
cellular_component rf 3 0.001 1.0 0.667 0.471
disease ct 13 0.003 0.983 0.366 0.411
disease el 13 0.003 0.982 0.341 0.398
disease ka 13 0.005 1.0 0.554 0.482
disease rf 13 0.003 0.98 0.362 0.41
genetic_interaction ct 47 0.0 1.0 0.389 0.332
genetic_interaction el 47 0.0 1.0 0.418 0.347
genetic_interaction ka 47 0.0 1.0 0.915 0.279
genetic_interaction rf 47 0.0 1.0 0.407 0.342
molecular_function ct 4 0.0 1.0 0.25 0.433
molecular_function el 4 0.0 0.001 0.0 0.0
molecular_function ka 4 0.0 0.001 0.001 0.0
molecular_function rf 4 0.0 0.001 0.0 0.0
pathway ct 26 0.001 0.994 0.064 0.189
pathway el 26 0.001 0.131 0.031 0.039
pathway ka 26 0.001 1.0 0.286 0.434
pathway rf 26 0.001 0.105 0.026 0.031
phenotype ct 12 0.0 0.918 0.291 0.342
phenotype el 12 0.0 1.0 0.298 0.362
phenotype ka 12 0.001 1.0 0.668 0.469
phenotype rf 12 0.0 1.0 0.296 0.358
protein_interaction ct 53 0.0 0.741 0.024 0.105
protein_interaction el 53 0.0 0.779 0.027 0.111
protein_interaction ka 53 0.001 1.0 0.214 0.402
protein_interaction rf 53 0.0 0.74 0.023 0.104

Table 2. Backup position values for every kernel after integration

Integration Kernel Elements Min Max Average Standard_Deviation
integration_mean_by_presence ct 53 0.0 0.22 0.015 0.038
integration_mean_by_presence el 53 0.0 0.128 0.009 0.023
integration_mean_by_presence ka 53 0.0 1.0 0.079 0.263
integration_mean_by_presence rf 53 0.0 0.323 0.016 0.045
mean ct 53 0.0 0.223 0.014 0.04
mean el 53 0.0 0.12 0.009 0.023
mean ka 53 0.0 1.0 0.08 0.263
mean rf 53 0.0 0.352 0.021 0.054

CDF plots of non integrated kernels

CDF plots of integrated kernels